Document Detail


A role for SIRT1 in the hypoxic response.
MedLine Citation:
PMID:  20620950     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1alpha and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes.
Authors:
Scott F Leiser; Matt Kaeberlein
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Molecular cell     Volume:  38     ISSN:  1097-4164     ISO Abbreviation:  Mol. Cell     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802571     Medline TA:  Mol Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-80     Citation Subset:  -    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pathology, University of Washington, Seattle, WA 98195, USA.
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Comment On:
Mol Cell. 2010 Jun 25;38(6):864-78   [PMID:  20620956 ]

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