Document Detail


Role of Rho-ROCK signaling in MOLT4 cells metastasis induced by CCL25.
MedLine Citation:
PMID:  20855113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our previous research has revealed that binding of the chemokine CCL25 to the CCR9 provides chemotactic cues guiding leukemic cells to specific tissues and organs. The RhoA-ROCK pathway might be involved in cancer migration. The purpose of this study was to explore the role of the RhoA-ROCK-MLC axis in leukemic cell migration following exposure to CCL25. The results showed that CCL25 could increase the amount of the GTPase RhoA and activate MLC in MOLT4 cells in a time-dependent manner. C3 exoenzyme and Y-27632 could block MOLT4 cell migration and chemotaxis. Thus, the RhoA-ROCK-MLC axis might play an important role in MOLT4 cell metastasis induced by CCL25.
Authors:
Li Zhang; Beibei Yu; Meng Hu; Zhan Wang; Dongying Liu; Xiaoling Tong; Jun Leng; Beibei Zhou; Yi Hu; Ranran Wu; Qianshan Ding; Qiuping Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-19
Journal Detail:
Title:  Leukemia research     Volume:  35     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Immunology, College of Basic Medical Science, Wuhan University, 185 Donghu Road, Wuhan, 430071 Hubei, China.
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Chemokines, CC / physiology*
Humans
Neoplasm Metastasis*
rho-Associated Kinases / metabolism*
rhoA GTP-Binding Protein / metabolism*
Chemical
Reg. No./Substance:
0/CCL25 protein, human; 0/Chemokines, CC; 0/ROCK1 protein, human; EC 2.7.11.1/rho-Associated Kinases; EC 3.6.5.2/rhoA GTP-Binding Protein

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