| The role of regulatory T cells in contact hypersensitivity. | |
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MedLine Citation:
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PMID: 20222867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regulatory T cells (Tregs) are one of the T cell subsets that have strong immune-suppressive activity. Contact hypersensitivity (CHS), clinically manifested as contact dermatitis, is one of the most frequently used mouse models to address cutaneous immune responses, and is composed of two phases: sensitization and elicitation. Recently, the role of Tregs in CHS has been investigated using newly generated genetically engineered mice. In this review, we will provide an overview of recent patents and the mechanism of Treg-mediated immunosuppression especially in terms of IL-10, CD39, CTLA-4, and RANKL, and discuss the role of Tregs in CHS during the sensitization and elicitation phases. |
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Authors:
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Tetsuya Honda; Yoshiki Miyachi; Kenji Kabashima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Recent patents on inflammation & allergy drug discovery Volume: 4 ISSN: 1872-213X ISO Abbreviation: Recent Pat Inflamm Allergy Drug Discov Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-06 Revised Date: 2011-06-17 |
Medline Journal Info:
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Nlm Unique ID: 101309297 Medline TA: Recent Pat Inflamm Allergy Drug Discov Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 85-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dermatitis, Contact / immunology* Disease Models, Animal Genetic Engineering Humans Immunosuppression* Mice Mice, Transgenic Patents as Topic T-Lymphocytes, Regulatory / immunology* |
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