Document Detail


On the role of regulatory T cells during viral-induced inflammatory lesions.
MedLine Citation:
PMID:  23129753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ocular HSV-1 infection can result in stromal keratitis, a blinding immunoinflammatory lesion that represents an immunopathological response to the infection. CD4(+) T cells are the main orchestrators, and lesions are more severe if the regulatory T cell (Treg) response is compromised from the onset of infection. Little is known about the role of Foxp3(+)CD4(+) Tregs during ongoing inflammatory reactions, which is the topic of this article. We used DEREG mice and depleted Tregs at different times postinfection. We show that lesions became more severe even when depletion was begun in the clinical phase of the disease. This outcome was explained both by Tregs' influence on the activity of inflammatory effector T cells at the lesion site and by an effect in lymphoid tissues that led to reduced numbers of effectors and less trafficking of T cells and neutrophils to the eye. Our results demonstrate that Tregs can beneficially influence the impact of ongoing tissue-damaging responses to a viral infection and imply that therapies boosting Treg function in the clinical phase hold promise for controlling a lesion that is an important cause of human blindness.
Authors:
Tamara Veiga-Parga; Amol Suryawanshi; Sachin Mulik; Fernanda Giménez; Shalini Sharma; Tim Sparwasser; Barry T Rouse
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-05
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  189     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-02-21     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5924-33     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Forkhead Transcription Factors / genetics
Genes, Reporter / immunology
Herpesvirus 1, Human / immunology*
Inflammation / genetics,  immunology,  virology
Keratitis, Herpetic / genetics,  immunology*,  pathology
Lymph Nodes
Mice
Mice, Inbred C57BL
T-Lymphocytes, Regulatory / immunology*,  pathology,  virology*
Th1 Cells / immunology,  pathology,  virology
Grant Support
ID/Acronym/Agency:
AI 06335/AI/NIAID NIH HHS; EY 005093/EY/NEI NIH HHS; R01 AI063365/AI/NIAID NIH HHS; R01 EY005093/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Forkhead Transcription Factors; 0/Foxp3 protein, mouse
Comments/Corrections

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