Document Detail


Role of recombination activating genes in the generation of antigen receptor diversity and beyond.
MedLine Citation:
PMID:  23039142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
V(D)J recombination is the process by which antibody and T-cell receptor diversity is attained. During this process, antigen receptor gene segments are cleaved and rejoined by non-homologous DNA end joining for the generation of combinatorial diversity. The major players of the initial process of cleavage are the proteins known as RAG1 (recombination activating gene 1) and RAG2. In this review, we discuss the physiological function of RAGs as a sequence-specific nuclease and its pathological role as a structure-specific nuclease. The first part of the review discusses the basic mechanism of V(D)J recombination, and the last part focuses on how the RAG complex functions as a sequence-specific and structure-specific nuclease. It also deals with the off-target cleavage of RAGs and its implications in genomic instability.
Authors:
Mayilaadumveettil Nishana; Sathees C Raghavan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunology     Volume:  137     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-21     Completed Date:  2013-02-26     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-81     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Immunology © 2012 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies / genetics*,  metabolism
DNA-Binding Proteins / genetics*
Genes, RAG-1 / physiology*
Genetic Variation
Humans
Receptors, Antigen, T-Cell / genetics*,  metabolism
V(D)J Recombination / genetics
Chemical
Reg. No./Substance:
0/Antibodies; 0/DNA-Binding Proteins; 0/Receptors, Antigen, T-Cell; 0/V(D)J recombination activating protein 2
Comments/Corrections

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