| Role of prostaglandin E2 in peptidoglycan mediated iNOS expression in mouse peritoneal macrophages in vitro. | |
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MedLine Citation:
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PMID: 20837010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many extracellular stimuli, e.g. microbial products, cytokines etc., result in the expression of inducible nitric oxide synthase (iNOS) in macrophages. However, it is not known whether expression of the iNOS gene in response to microbial products is a primary response of macrophages, or is the result of paracrine/autocrine signalling induced by endogenous biomolecules that are synthesised as a result of host cell-microbe interaction. In this paper we demonstrate that iNOS expression in mouse peritoneal macrophages in response to bacterial peptidoglycan (PGN) is a secondary effect requiring autocrine signalling of endogenously produced prostaglandin E2, and that PGN stimulation is mandatory, but not sufficient in itself, for induction of iNOS expression. |
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Authors:
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Yogesh Dahiya; Rajeev Kumar Pandey; Kunal H Bhatt; Ajit Sodhi |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-17 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4227-32 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autocrine Communication / drug effects Base Sequence Cyclooxygenase 2 / genetics, metabolism Dinoprostone / metabolism*, pharmacology Female Gene Expression / drug effects Host-Pathogen Interactions Macrophages, Peritoneal / drug effects*, metabolism* Male Mice Mice, Inbred BALB C Nitric Oxide Synthase Type II / antagonists & inhibitors, genetics* Peptidoglycan / pharmacology* RNA, Messenger / genetics, metabolism RNA, Small Interfering / genetics |
| Chemical | |
Reg. No./Substance:
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0/Peptidoglycan; 0/RNA, Messenger; 0/RNA, Small Interfering; 363-24-6/Dinoprostone; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nos2 protein, mouse; EC 1.14.99.-/Ptgs2 protein, mouse; EC 1.14.99.1/Cyclooxygenase 2 |
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