| The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism. | |
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MedLine Citation:
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PMID: 20502053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prokineticin system comprises two multifunctional secreted proteins, prokineticin-1 (PROK1) and prokineticin-2 (PROK2), and their cognate G protein-coupled receptors. The prokineticins were originally identified as endogenous regulators of gastrointestinal motility. Currently, these bioactive peptides are involved in a wide spectrum of biological functions, including angiogenesis, neurogenesis, circadian rhythms, nociception, hematopoiesis and immune response. Mice homozygous for null mutations in Prokr2 or Prok2 recapitulate the human phenotype of Kallmann syndrome, exhibiting severe atrophy of the reproductive system and hypoplastic olfactory bulbs. Indeed, the evidence from several naturally inactivating mutations in the PROK2 and PROKR2 genes in patients with Kallmann syndrome and normosmic hypogonadotropic hypogonadism also indicate the essential role of PROK2 in olfactory bulb morphogenesis and GnRH secretion in humans. |
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Authors:
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Ana Paula Abreu; Ursula B Kaiser; Ana Claudia Latronico |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-05-21 |
Journal Detail:
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Title: Neuroendocrinology Volume: 91 ISSN: 1423-0194 ISO Abbreviation: Neuroendocrinology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-14 Completed Date: 2010-11-04 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 0035665 Medline TA: Neuroendocrinology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 283-90 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular, LIM/42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Gastrointestinal Hormones / genetics*, metabolism Humans Hypogonadism / genetics*, metabolism Male Mice Mutation Neuropeptides / genetics*, metabolism Receptors, G-Protein-Coupled / genetics*, metabolism Receptors, Peptide / genetics*, metabolism Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / genetics*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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U54 HD28138/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Hormones; 0/Neuropeptides; 0/PROK2 protein, human; 0/PROKR1 protein, human; 0/PROKR2 protein, human; 0/Receptors, G-Protein-Coupled; 0/Receptors, Peptide; 0/Vascular Endothelial Growth Factor, Endocrine-Gland-Derived |
| Comments/Corrections | |
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