| Role of proinflammatory cytokines and redox homeostasis in exercise-induced delayed progression of hypertension in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 19841289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension is a well-known risk factor for various cardiovascular diseases. Recently, exercise has been recommended as a part of lifestyle modification for all hypertensive patients. However, the precise mechanisms of exercise training (ExT)-induced effects on the development of hypertension are poorly understood. Therefore, we hypothesized that chronic ExT would delay the progression of hypertension in young spontaneously hypertensive rats (SHRs). In addition, we explored whether the beneficial effects of chronic ExT were mediated by reduced proinflammatory cytokines and improved redox status. We also investigated the involvement of nuclear factor-kappaB in exercise-induced effects. To test our hypotheses, young normotensive (Wistar-Kyoto) and SHRs were given moderate-intensity ExT for 16 weeks. Blood pressure was determined by the tail-cuff method, and cardiac function was assessed by echocardiography. Myocardial total reactive oxygen species and superoxide production were measured by electron paramagnetic resonance spectroscopy; tumor necrosis factor-alpha, interleukin-1beta, gp91(phox), and inducible NO synthase by real-time PCR; and nuclear factor kappaB activity by electrophoretic mobility shift assay. Chronic ExT in hypertensive rats resulted in significantly reduced blood pressure, reduced concentric hypertrophy, and improved diastolic function. ExT significantly reduced proinflammatory cytokines and inducible NO synthase, attenuated total reactive oxygen species and superoxide production, and increased antioxidants in SHRs. ExT also resulted in increased NO production and decreased nuclear factor kappaB activity in SHRs. In summary, chronic ExT delays the progression of hypertension and improves cardiac function in young SHRs; these ExT-induced beneficial effects are mediated by reduced proinflammatory cytokines and improved redox homeostasis via downregulation of nuclear factor-kappaB. |
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Authors:
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Deepmala Agarwal; Masudul Haque; Srinivas Sriramula; Nithya Mariappan; Romain Pariaut; Joseph Francis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-10-19 |
Journal Detail:
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Title: Hypertension Volume: 54 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2009-12-17 Revised Date: 2011-03-03 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 1393-400 Citation Subset: IM |
Affiliation:
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Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, 1909 Skip Bertman Dr, Baton Rouge, LA 70803, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Body Weight / physiology Cardiomegaly / immunology, metabolism, physiopathology Diastole / physiology Disease Progression Homeostasis / physiology Hypertension / immunology*, metabolism, physiopathology Interleukin-1beta / metabolism* Male Membrane Glycoproteins / metabolism NADPH Oxidase / metabolism NF-kappa B / metabolism Nitric Oxide / metabolism Nitric Oxide Synthase Type II / metabolism* Norepinephrine / blood Oxidation-Reduction Peroxynitrous Acid / metabolism Physical Exertion / physiology* Rats Rats, Inbred SHR Rats, Inbred WKY Tumor Necrosis Factor-alpha / metabolism* Ventricular Function, Left / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-80544/HL/NHLBI NIH HHS; R01 HL080544-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1beta; 0/Membrane Glycoproteins; 0/NF-kappa B; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide; 14691-52-2/Peroxynitrous Acid; 51-41-2/Norepinephrine; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nos2 protein, rat; EC 1.6.-/Cybb protein, rat; EC 1.6.3.1/NADPH Oxidase |
| Comments/Corrections | |
Comment In:
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Hypertension. 2009 Dec;54(6):1206-8
[PMID:
19841287
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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