Document Detail


The Role of Polyunsaturated ω-3 Fatty Acid Eicosapentaenoic Acid-Derived Resolvin E1 (RvE1) in Bone Preservation.
MedLine Citation:
PMID:  24941160     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Resolvin E1 (RvE1) is a recently discovered lipid-derived mediator that is endogenously synthesized from the polyunsaturated fatty acid eicosapentaenoic acid. RvE1 is locally generated in response to inflammation where it enhances the resolution phase of inflammation by diminishing neutrophil chemotaxis and by enhancing nonphlogistic macrophage-directed clearance of apoptotic neutrophils. RvE1 was also found to be effective in preventing and restoring bone loss in the inflammatory bone disease periodontitis. This review examines experimental evidence on RvEl's actions in bone. Current data indicate that in addition to anti-inflammatory actions, RvE1 also directly acts on bone cells and promotes bone preservation.
Authors:
Robert Gyurko; Thomas E Van Dyke
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical reviews in immunology     Volume:  34     ISSN:  1040-8401     ISO Abbreviation:  Crit. Rev. Immunol.     Publication Date:  2014  
Date Detail:
Created Date:  2014-06-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914819     Medline TA:  Crit Rev Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347-57     Citation Subset:  IM    
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