| The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size. | |
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MedLine Citation:
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PMID: 20444918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Context: The high incidence of insulin resistance, type 2 diabetes, and metabolic syndrome in Western societies and their impact on quality of life emphasize the importance of identifying underlying susceptibility loci for metabolic diseases. The polycystic ovary syndrome (PCOS) susceptibility locus D19S884 allele 8 (A8) is associated with measures of insulin resistance, beta-cell dysfunction, and other metabolic phenotypes in PCOS families. We now investigate the role of D19S884 A8 in pregnancy. Objective: Using the multiethnic Hyperglycemia and Adverse Pregnancy Outcome cohort, we assessed the associations of D19S884 A8 with measures of maternal glycemia and fetal size. Design: We tested for association of maternal D19S884 A8 with maternal outcomes (fasting, 1-h, and 2-h plasma glucose, and fasting and 1-h C-peptide from an oral glucose tolerance test) and fetal and maternal D19S884 A8 with fetal outcomes (birth weight, length, head circumference, sum of skin folds, fat mass, cord C-peptide, and 2-h neonatal plasma glucose). Subjects: We analyzed 4424 Caucasian mothers and 3347 offspring of northern European ancestry, 1957 Thai mothers and 2089 offspring from Bangkok, 1208 Afro-Caribbean mothers and 1209 offspring from Barbados, and 774 Hispanic mothers and 762 offspring from Bellflower, California. Results: After adjusting for confounding variables and multiple testing, neither maternal nor fetal D19S884 A8 showed significant evidence for association with any of the outcomes tested. Conclusions: The PCOS susceptibility locus, D19S884 A8, is not a major factor contributing to glycemia during pregnancy or fetal size in a general obstetric population. |
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Authors:
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C M Ackerman; L P Lowe; H Lee; F Chen; E Hughes; P Cholod; A R Dyer; M G Hayes; B E Metzger; W L Lowe; M Urbanek; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-05 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-07-26 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 3242-50 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 15-717, Chicago, IL 60611, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Birth Weight / genetics Blood Glucose / genetics* C-Peptide / genetics Female Fetal Development / genetics* Genetic Association Studies Genetic Predisposition to Disease / genetics* Genotype Humans Insulin Resistance / genetics Polycystic Ovary Syndrome / genetics Pregnancy Pregnancy Outcome / genetics |
| Grant Support | |
ID/Acronym/Agency:
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P50 HD44405/HD/NICHD NIH HHS; R01-HD34242/HD/NICHD NIH HHS; R01-HD34243/HD/NICHD NIH HHS; R01DK067459/DK/NIDDK NIH HHS; U01HG004415/HG/NHGRI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/C-Peptide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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