| Role of plasmacytoid dendritic cells in lung-associated inflammation. | |
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MedLine Citation:
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PMID: 20394583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators. One of the most important features of pDCs is the high production of IFN type I that can promote the polarization of T cells towards a Th1 phenotype. Recent evidence has highlighted the relevance of pDCs in therapy for asthma, lung infections and cancer. However, it is to note that pDCs can also participate in suppressive networks via the recruitment of T regulatory cells. Further studies are needed to understand pDCs activity in the lung, not only to elucidate pathological mechanisms, but also to lead towards new therapeutic approaches for lung inflammatory-based diseases. The article also outlines recent patents on plasmacytoid DCs. |
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Authors:
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Rosalinda Sorrentino; Silvana Morello; Aldo Pinto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Recent patents on inflammation & allergy drug discovery Volume: 4 ISSN: 1872-213X ISO Abbreviation: Recent Pat Inflamm Allergy Drug Discov Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-06 Revised Date: 2011-06-17 |
Medline Journal Info:
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Nlm Unique ID: 101309297 Medline TA: Recent Pat Inflamm Allergy Drug Discov Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 138-43 Citation Subset: IM |
Affiliation:
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Pharmaceutical Sciences Department, University of Salerno, Salerno, Italy. rosalinda.sorrentino@googlemail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dendritic Cells / immunology* Humans Interferon Type I / immunology Patents as Topic Pneumonia / immunology* T-Lymphocytes, Regulatory / immunology* Th1 Cells / immunology |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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