Document Detail

Role of placental growth factor in mesenteric neoangiogenesis in a mouse model of portal hypertension.
MedLine Citation:
PMID:  19751735     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Portal hypertension is responsible for the major complications associated with cirrhosis. Angiogenesis has been associated with the pathophysiology of portal hypertension. We investigated the role of placental growth factor (PlGF) and tested the effects of monoclonal antibodies against PlGF (alphaPlGF) in a mouse model of portal hypertension. METHODS: Using a mouse model of prehepatic portal hypertension, we measured PlGF levels in the mesenteric tissue at different time points. We used knockout mice and alphaPlGF to determine the role of PlGF in the splanchnic hyperdynamic system and portosystemic collateral formation, examining its effects before and after portal hypertension was induced. RESULTS: PlGF was significantly up-regulated in the mesenteric tissue of mice with portal hypertension. Compared with wild-type animals, the vascular density in the mesentery was reduced in PlGF knockout hypertensive mice, preventing collateral formation and attenuation of mesenteric artery flow without affecting portal pressure. In the prevention study, alphaPlGF showed similar findings as in the knockout study. In mice with portal hypertension, administration of alphaPlGF resulted in a 32% decrease in portal pressure, compared with mice given immunoglobulin G(1) (control). CONCLUSIONS: Pathologic angiogenesis in the mesenteric tissues of mice with portal hypertension is mediated by PlGF. Blocking PlGF could be an effective strategy for reducing collateral formation and lowering portal pressure; further research into the effects in cirrhosis is warranted.
Christophe Van Steenkiste; Anja Geerts; Eline Vanheule; Hans Van Vlierberghe; Filip De Vos; Kim Olievier; Christophe Casteleyn; Debby Laukens; Martine De Vos; Jean-Marie Stassen; Peter Carmeliet; Isabelle Colle
Related Documents :
16801365 - Renovascular impedance correlates with portal pressure in patients with liver cirrhosis.
7338875 - Egg transport and postcoital isthmic contractility in the rabbit.
3303595 - Varicocele.
1336475 - Effect of enalapril treatment and sclerotherapy of esophageal varices on hepatic hemody...
2942535 - Pressure-induced dissociation of solubilized sarcoplasmic reticulum atpase.
2010405 - Mechanisms of blood flow during pneumatic vest cardiopulmonary resuscitation.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-12
Journal Detail:
Title:  Gastroenterology     Volume:  137     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2009-12-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2112-24.e1-6     Citation Subset:  AIM; IM    
Faculty of Medicine and Health Sciences, Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angiogenic Proteins / metabolism
Antibodies, Monoclonal / pharmacology
Antihypertensive Agents / pharmacology
Collateral Circulation* / drug effects
Disease Models, Animal
Hypertension, Portal / drug therapy,  metabolism*,  physiopathology
Mesentery / blood supply*,  metabolism*
Mice, Knockout
Neovascularization, Pathologic / metabolism*,  physiopathology,  prevention & control
Portal Pressure
Pregnancy Proteins / deficiency,  genetics,  immunology,  metabolism*
Signal Transduction
Splanchnic Circulation* / drug effects
Reg. No./Substance:
0/Angiogenic Proteins; 0/Antibodies, Monoclonal; 0/Antihypertensive Agents; 0/Pregnancy Proteins; 144589-93-5/placenta growth factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in st...
Next Document:  Endocrine mediated phenotypic plasticity: Condition-dependent effects of juvenile hormone on dominan...