| Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR. | |
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MedLine Citation:
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PMID: 21765832 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of receptor endocytosis. However, the identities of the kinases involved in this process remained largely unknown until recently. This paper discusses advances in our knowledge of the important role played by protein phosphorylation in the regulation of the endocytic machinery and how phosphorylation controls the coated vesicle cycle. |
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Authors:
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Frederic Delom; Delphine Fessart |
Publication Detail:
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Type: Journal Article Date: 2011-06-07 |
Journal Detail:
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Title: International journal of cell biology Volume: 2011 ISSN: 1687-8884 ISO Abbreviation: Int J Cell Biol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101517861 Medline TA: Int J Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 246954 Citation Subset: - |
Affiliation:
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Bordeaux Cardiothoracic Research Center, Bordeaux University, 146, Léo-Saignat, 33076 Bordeaux, France. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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