Document Detail


Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR.
MedLine Citation:
PMID:  21765832     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of receptor endocytosis. However, the identities of the kinases involved in this process remained largely unknown until recently. This paper discusses advances in our knowledge of the important role played by protein phosphorylation in the regulation of the endocytic machinery and how phosphorylation controls the coated vesicle cycle.
Authors:
Frederic Delom; Delphine Fessart
Publication Detail:
Type:  Journal Article     Date:  2011-06-07
Journal Detail:
Title:  International journal of cell biology     Volume:  2011     ISSN:  1687-8884     ISO Abbreviation:  Int J Cell Biol     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517861     Medline TA:  Int J Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246954     Citation Subset:  -    
Affiliation:
Bordeaux Cardiothoracic Research Center, Bordeaux University, 146, Léo-Saignat, 33076 Bordeaux, France.
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