| Role for PPARgamma in IL-2 inhibition in T cells by Echinacea-derived undeca-2E-ene-8,10-diynoic acid isobutylamide. | |
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MedLine Citation:
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PMID: 19712756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Certain fatty acid amides from Echinacea spp. have demonstrated moderate to high cannabinoid activity. As a result, CB2 activation is currently hypothesized to be the basis of activity for immunomodulation by Echinacea spp. PPARgamma, an orphan nuclear receptor and lipid sensor, is known to inhibit IL-2 production and be activated by fatty acid derivatives such as the endocannabinoids. In these investigations, we demonstrate that undeca-2E-ene-8,10-diynoic acid, an Echinacea angustifolia-derived alkylamide lacking affinity for the CB2 receptor, inhibits IL-2 secretion in Jurkat T cells through PPARgamma activity at low micromolar concentrations (330 ng/mL). The IL-2 inhibition is reversed by the addition of the selective PPARgamma antagonist T0070907. Additionally, we show that that undeca-2-ene-8,10-diynoic acid stimulates 3T3-L1 differentiation, a process dependent on PPARgamma activity. These experiments demonstrate that PPARgamma is involved in T cell IL-2 inhibition by undeca-2-ene-8,10-diynoic acid and suggest that cytokine modulation by the alkylamides is due to polyvalent activity. |
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Authors:
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Kevin Spelman; Katrina Iiams-Hauser; Nadja B Cech; Ethan Will Taylor; Nicholas Smirnoff; Cynthia A Wenner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-08-25 |
Journal Detail:
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Title: International immunopharmacology Volume: 9 ISSN: 1878-1705 ISO Abbreviation: Int. Immunopharmacol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1260-4 Citation Subset: IM |
Affiliation:
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University of North Carolina Greensboro, Department of Chemistry and Biochemistry, P.O. Box 26170, Greensboro, NC 27405, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3T3-L1 Cells Animals Benzamides / pharmacology Cell Differentiation / drug effects, physiology Cell Survival / drug effects Drug Interactions Echinacea / metabolism Humans Interleukin-2 / antagonists & inhibitors*, secretion Jurkat Cells Mice PPAR gamma / antagonists & inhibitors, physiology* Polyunsaturated Alkamides / pharmacology* Pyridines / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Benzamides; 0/Interleukin-2; 0/PPAR gamma; 0/Polyunsaturated Alkamides; 0/Pyridines; 0/T 0070907 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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