| Role of PD-1 in regulating T-cell immunity. | |
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MedLine Citation:
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PMID: 21061197 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers negative signals upon interaction with its two ligands, PD-L1 or PD-L2. PD-1 and its ligands are broadly expressed and exert a wider range of immunoregulatory roles in T cells activation and tolerance compared with other CD28 members. Subsequent studies show that PD-1-PD-L interaction regulates the induction and maintenance of peripheral tolerance and protect tissues from autoimmune attack. PD-1 and its ligands are also involved in attenuating infectious immunity and tumor immunity, and facilitating chronic infection and tumor progression. The biological significance of PD-1 and its ligand suggests the therapeutic potential of manipulation of PD-1 pathway against various human diseases. In this review, we summarize our current understanding of PD-1 and its ligands ranging from discovery to clinical significance. |
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Authors:
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Hyun-Tak Jin; Rafi Ahmed; Taku Okazaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current topics in microbiology and immunology Volume: 350 ISSN: 0070-217X ISO Abbreviation: Curr. Top. Microbiol. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0110513 Medline TA: Curr Top Microbiol Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 17-37 Citation Subset: IM |
Affiliation:
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Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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