| Role of PARP under stress conditions: cell death or protection? | |
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MedLine Citation:
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PMID: 12608693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A great deal of increasing evidence designs PARP as a multifunctional protein implicated in many cellular functions. Much interest is emerging to understand the precise mechanisms by which PARP mediates genome stabilization and protection against damage, as well as its involvement in cell death, either apoptotic or necrotic. Aside from the clearly established role of PARP hyperactivation in necrotic cell death, after excessive DNA damage and energy failure, it appears to be actively involved in the phenomenon of apoptosis. However, its exact role is still controversial. The identification of several enzymes sharing the poly(ADP-ribose) polymerase catalytic domain (PARPs), but with different features and subcellular localization, has opened a new perspective in the field of poly(ADP-ribosyl)ation. The picture of the role of PARP in the control of cell homeostasis became even more complex after demonstration of its implication in the regulation of gene transcription. The notion that energy failure is the sole mechanism by which PARP promotes cell death is therefore under reevaluation. |
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Authors:
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Vincenzo Giuseppe Nicoletti; Anna Maria Giuffrida Stella |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Neurochemical research Volume: 28 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-28 Completed Date: 2003-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 187-94 Citation Subset: IM |
Affiliation:
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Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, University of Catania, Viale A. Doria 6, 95125 Catania, Italy. nicovigi@unict.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Death* Cell Survival* DNA Damage Gene Expression Regulation Oxidative Stress* Poly(ADP-ribose) Polymerases / metabolism* |
| Chemical | |
Reg. No./Substance:
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EC 2.4.2.30/Poly(ADP-ribose) Polymerases |
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