Document Detail


Role of PAPP-A in aging and age-related disease.
MedLine Citation:
PMID:  22790018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.
Authors:
Cheryl A Conover
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-10
Journal Detail:
Title:  Experimental gerontology     Volume:  48     ISSN:  1873-6815     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-17     Completed Date:  2014-02-20     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  612-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aging / metabolism*,  pathology
Animals
Atherosclerosis / metabolism*,  pathology
Humans
Neoplasms / metabolism*,  pathology
Pregnancy-Associated Plasma Protein-A / metabolism*
Grant Support
ID/Acronym/Agency:
AG028141/AG/NIA NIH HHS; HL074871/HL/NHLBI NIH HHS; R01 AG028141/AG/NIA NIH HHS; R01 HL074871/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A
Comments/Corrections

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