| The Role of Oxidative Stress in the Pathophysiology of Gestational Diabetes Mellitus. | |
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MedLine Citation:
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PMID: 21675877 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy, it plays important roles in embryo development, implantation, placental development and function, foetal development, and labour. However, pathologic pregnancies including gestational diabetes mellitus (GDM) are associated with a heightened level of oxidative stress, owing to both over production of free radicals and/or a defect in the antioxidant defences. This has important implications on the mother, placental function, and foetal wellbeing. Animal models of diabetes have confirmed the important role of oxidative stress in the aetiology of congenital malformations; the relative immaturity of the antioxidant system facilitates the exposure of embryos and fetuses to the damaging effects of oxidative stress. Of note, there are only a few clinical studies evaluating the potential beneficial effects of antioxidants in GDM. Thus, whether or not increased antioxidant intake can reduce the complications of GDM in both mother and foetus needs to be explored. This review provides an overview and updated data on our current understanding of the complications associated with oxidative changes in GDM. |
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Authors:
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M Lappas; Ursula Hiden; Julia Froehlich; Gernot Desoye; Sylvie Haugel-de Mouzon; Alicia Jawerbaum |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-15 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: - ISSN: 1557-7716 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Melbourne, Obstetrics & Gynaecology, Mercy Hospital for Women, 4th Floor / 163 Studley Road, Heidelberg, Victoria, Australia, 3084; mlappas@unimelb.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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