| Role of the Nitric Oxide on Relaxation of the Human Umbilical Artery during Cooling. | |
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MedLine Citation:
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PMID: 21532262 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In the present study, the effects of cooling (to 28°C) on the vasodilatation induced by diazoxide (10(-9)-3×10(-4) M), isoproterenol (10(-9)-3×10(-4) M) and magnesium sulphate (0.1-30 mM) on serotonin-pre-contracted human umbilical artery and the role of nitric oxide in these effects were analyzed. Diazoxide, isoproterenol and magnesium produced concentration-dependent relaxation of human umbilical artery precontracted with serotonin (10(-6) M). During cooling, the pIC(50) values and maximal responses to these agents were significantly lower than at 37°C. Cooling to 28°C in the presence of N(G)-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) did not modify the effects of temperature on diazoxide, isoproterenol and magnesium-induced relaxations. These results suggest that cooling-induced changes of diazoxide, isoproterenol, and magnesium sulphate in human umbilical artery are independent of nitric oxide. |
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Authors:
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K E Nurullahoğlu Atalik; Z U Nurullahoğlu; M Kiliç |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Volume: 131 ISSN: 1347-5231 ISO Abbreviation: Yakugaku Zasshi Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413613 Medline TA: Yakugaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 661-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Meram Medicine, University of Selçuk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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