Document Detail

Role of neurotransmitter gases in the control of the carotid body in heart failure.
MedLine Citation:
PMID:  22842006     Owner:  NLM     Status:  MEDLINE    
The peripheral arterial chemoreflex, arising primarily from the carotid body in most species, plays an important role in the control of breathing and in autonomic control of cardiovascular function. The peripheral chemoreflex is enhanced in heart failure patients and animal models of heart failure and contributes to the sympathetic hyperactivity and breathing instability that exacerbates the progression of the disease. Studies in animal models have shown that carotid body chemoreceptor activity is enhanced under both normoxic and hypoxic conditions in heart failure due to disruption of local mediators that control carotid body function. This brief review highlights evidence that the alterations in the gasotransmitters, nitric oxide, carbon monoxide, and hydrogen sulfide in the carotid body contribute to the exaggerated carotid body function observed in heart failure.
Harold D Schultz; Rodrigo Del Rio; Yanfeng Ding; Noah J Marcus
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-25
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  184     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-04-15     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  197-203     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Carbon Monoxide / physiology*
Carotid Body / physiopathology*
Heart Failure / physiopathology*
Hydrogen Sulfide*
Neurotransmitter Agents / physiology*
Nitric Oxide / physiology*
Grant Support
Reg. No./Substance:
0/Gases; 0/Neurotransmitter Agents; 31C4KY9ESH/Nitric Oxide; 7U1EE4V452/Carbon Monoxide; YY9FVM7NSN/Hydrogen Sulfide

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