| Role of neurotransmitter gases in the control of the carotid body in heart failure. | |
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MedLine Citation:
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PMID: 22842006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The peripheral arterial chemoreflex, arising primarily from the carotid body in most species, plays an important role in the control of breathing and in autonomic control of cardiovascular function. The peripheral chemoreflex is enhanced in heart failure patients and animal models of heart failure and contributes to the sympathetic hyperactivity and breathing instability that exacerbates the progression of the disease. Studies in animal models have shown that carotid body chemoreceptor activity is enhanced under both normoxic and hypoxic conditions in heart failure due to disruption of local mediators that control carotid body function. This brief review highlights evidence that the alterations in the gasotransmitters, nitric oxide, carbon monoxide, and hydrogen sulfide in the carotid body contribute to the exaggerated carotid body function observed in heart failure. |
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Authors:
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Harold D Schultz; Rodrigo Del Rio; Yanfeng Ding; Noah J Marcus |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-07-25 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 184 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-29 Completed Date: 2013-04-15 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 197-203 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Integrative/Cellular Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, United States. hschultz@unmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Monoxide / physiology* Carotid Body / physiopathology* Gases* Heart Failure / physiopathology* Humans Hydrogen Sulfide* Neurotransmitter Agents / physiology* Nitric Oxide / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P01 HL062222/HL/NHLBI NIH HHS; P01-HL-62222/HL/NHLBI NIH HHS; P20 RR017675/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gases; 0/Neurotransmitter Agents; 10102-43-9/Nitric Oxide; 630-08-0/Carbon Monoxide; 7783-06-4/Hydrogen Sulfide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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