| Role of Neuropilin-1 and its expression in Egyptian Acute Myeloid and Acute Lymphoid Leukemia patients. | |
| | |
MedLine Citation:
|
PMID: 21978468 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Neuropilins are expressed in tumors vasculature and cells. Their expression is thought to be correlated with tumor angiogenesis and progression. In this study, we analyzed NRP-1 expression level in 40 acute leukemia patients [20 acute myeloid leukemia (AML) and 20 acute lymphoblastic leukemia (ALL)] and 10 healthy controls using Real-Time Quantitative Reverse-Transcriptase Polymerase Chain Reaction (RTQ-PCR) aiming to show Neuropilin-1 (NRP-1) gene expression pattern in acute leukemia patients and its role in disease severity and progression. NRP-1 was expressed in 80% and 95% of ALL and AML respectively with levels higher in patients than controls and in ALL than AML patients. NRP-1 levels were significantly correlated with blast percentage and complete remission. We conclude that NRP-1 is significantly associated with acute leukemia and that its level might serve as an indicator for disease severity and progression. NRP-1 signaling may represent a novel therapeutic approach for the treatment of acute leukemia subsets. |
| | |
Authors:
|
Sarah Younan; Shereen Elhoseiny; Amira Hammam; Rania Gawdat; Mohamed El-Wakil; Mohamed Fawzy |
Related Documents
:
|
11673318 - Visual and motor evoked potentials in the course of multiple sclerosis. 2549818 - Clinical recovery and train-of-four ratio measured mechanically and electromyographical... 7521288 - H reflex studies in neurolathyrism. 17822538 - Impaired cortical processing of inspiratory loads in children with chronic respiratory ... 3363028 - Slow potential correlates of frontal function, psychosis, and negative symptoms. 404878 - Pseudomonas aeruginosa bacteremia in a dialysis unit. 1. recognition of cases, epidemio... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-4 |
Journal Detail:
|
Title: Leukemia research Volume: - ISSN: 1873-5835 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Clinical and Chemical Pathology, Kasr El Aini Hospital, Cairo University, El Saraya Street, Infront of El Manial Palace, Cairo 11451, Egypt. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bortezomib resistance in a myeloma cell line is associated to PSM?5 overexpression and polyploidy.
Next Document: Effect of corpus callosotomy on attention deficit and behavioral problems in pediatric patients with...