Document Detail

Role of NO on pressure-natriuresis in Wistar-Kyoto and spontaneously hypertensive rats.
MedLine Citation:
PMID:  7679457     Owner:  NLM     Status:  MEDLINE    
We investigated the role of the endothelium-derived relaxing factor nitric oxide (NO) on pressure-natriuresis in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) using in vivo perfusion studies. Differences in the neural and hormonal background to the kidney were minimized by renal denervation and by holding plasma vasopressin, aldosterone, corticosterone, and norepinephrine levels constant by intravenous infusion. In WKY, elevation of renal perfusion pressure (RPP) from 115 to 157 mm Hg increased urinary sodium excretion 4.5 to 14.8 microEq/min/g kidney wt, and the slope of its linear regression was 0.21 microEq/min/g kidney wt/mm Hg. Infusion of an inhibitor of NO synthase, L-NMMA (1 mg/min/kg), lowered this slope (P < 0.05) but L-arginine (3 mg/min/kg) did not change it. By contrast, the impaired pressure-natriuresis response of SHR was ameliorated by L-arginine (slope: 0.08 to 0.16; P < 0.05), while L-NMMA did not blunt it further. GFR and renal plasma flow (RPF) were well autoregulated in both strains, but L-NMMA lowered RPF significantly (SHR: from 4.2 to 2.6 ml/min/g kidney wt; WKY: 4.5 to 2.5 ml/min/g kidney wt). Moreover, when infused simultaneously, all these individual effects of L-NMMA and L-arginine were nullified. These results suggest that NO plays an important role in the pressure-natriuresis mechanism.
H Ikenaga; H Suzuki; N Ishii; H Itoh; T Saruta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  43     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-18     Completed Date:  1993-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Amino Acid Oxidoreductases / antagonists & inhibitors
Arginine / analogs & derivatives,  pharmacology
Blood Pressure / drug effects,  physiology*
Hypertension / etiology,  physiopathology
Natriuresis / drug effects,  physiology*
Nitric Oxide / metabolism*
Nitric Oxide Synthase
Rats, Inbred SHR
Rats, Inbred WKY
Renal Circulation / drug effects,  physiology
Reg. No./Substance:
10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 74-79-3/Arginine; EC Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases

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