| The role of NK cells in the autoimmune thyroid disease-associated pregnancy loss. | |
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MedLine Citation:
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PMID: 20237962 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Pregnancy loss is a frequent event. Autoimmune thyroid disorders and altered natural killer (NK) cell functions are two distinct risk factors, which independently could induce adverse pregnancy outcome. Thyroid autoimmunity has been an object of increased attention by investigators in the context of pregnancy loss. Peripheral NK cells and uNK cells comprise distinct cell populations in terms of phenotype and function but they play an important role in the course of a normal human pregnancy via several potential functions. In autoimmune thyroid diseases, several abnormalities of killer cell activity have been described. The functional defects involving NK maturation and/or functional activation observed in Graves' disease patients could independently influence the reproductive outcome. This suggestion needs extensive investigation and could be important for the therapeutical approach in preventing pregnancy loss in patients with thyroid autoimmunity. |
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Authors:
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Emiliana Konova |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical reviews in allergy & immunology Volume: 39 ISSN: 1559-0267 ISO Abbreviation: Clin Rev Allergy Immunol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504368 Medline TA: Clin Rev Allergy Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 176-84 Citation Subset: IM |
Affiliation:
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Center for Reproductive Health, Medical University of Pleven, Pleven, Bulgaria. eikonova@abv.bg |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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