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Role of NF-κB in Hepatocarcinogenesis and Its Potential Inhibition by Dietary Antioxidants.
MedLine Citation:
PMID:  22873217     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this review, the role of nuclear factor-κB (NF-κB) in hepatocarcinogenesis is examined. The administration of several hepatic tumor promoters leads to the activation of NF-κB in the liver of rats and mice. Many studies support the hypothesis that the activation of NF-κB in the liver is inhibited by antioxidants. The role of NF-κB in hepatocarcinogenesis has been examined using NF-κB overexpression and knockout models. The role of NF-κB in liver carcinogenesis is complex; some models show that NF-κB contributes to carcinogenesis whereas others see no effect or an inhibition. Overall, although hepatic tumor promoting agents can activate NF-κB and this activation can be inhibited by antioxidants, the significance of this activation is unclear.
Authors:
Howard Perry Glauert
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-02
Journal Detail:
Title:  Current cancer drug targets     Volume:  -     ISSN:  1873-5576     ISO Abbreviation:  Curr Cancer Drug Targets     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094211     Medline TA:  Curr Cancer Drug Targets     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Graduate Center for Nutritional Sciences, University of Kentucky, 222 Funkhouser Building, Lexington, KY 40506-0054. hglauert@uky.edu.
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