Document Detail


The Role of Muscle Mass as a Modulator of Exercise-Induced Hyperemia.
MedLine Citation:
PMID:  24674856     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Exercise-induced hyperemia is often normalized for muscle mass and this value sometimes evaluated at relative exercise intensities, to take muscle recruitment into account. Therefore, this study sought to better understand the impact of muscle mass on leg blood flow (LBF) during exercise. LBF was assessed by Doppler ultrasound in 27 young healthy male subjects performing knee-extensor exercise (KE) at three absolute (5, 15, and 25W) and three relative (20, 40, and 60% of KEmax) workloads. Thigh muscle mass (5.2 - 8.1kg) and LBF was significantly correlated at rest (r=0.54; p=0.004). Exercise-induced hyperemia was linearly related to absolute workload, but revealed substantial between subject variability, documented by the coefficient of variation (CV) (5W: 17%; 15W: 16%; 25W: 16%). Quadriceps muscle mass (QMM) (1.5 - 2.7kg) and LBF were not correlated at 5, 15, or 25W (r=0.09-0.01; p=0.7-0.9). Normalizing blood flow for QMM did not improve the CV at each absolute workload (5W: 21%; 15W: 21%; 25W: 22%) while the additional evaluation at relative exercise intensities resulted in even greater variance (20% KEmax: 29%; 40% KEmax: 29%; 60% KEmax: 27%). Similar findings were documented when subjects were parsed into high and low aerobic capacity. Thus, in contrast to rest, blood flow during exercise is unrelated to muscle mass and simply normalizing for muscle mass or comparing normalized blood flow at a given relative exercise intensity has no effect on the inherent blood flow variability. Therefore, during exercise muscle mass does not appear to be a determinant of the hyperemic response.
Authors:
Ryan S Garten; H Jonathan Groot; Matthew Jordan Rossman; Jayson R Gifford; Russell S Richardson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-27
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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