Document Detail


Role of MicroRNAs in Cardiac Remodeling and Heart Failure.
MedLine Citation:
PMID:  21431305     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) are endogenous, short (~22 nucleotide), evolutionarily conserved, non-coding RNAs that regulate gene expression at the post-transcriptional level. Recent evidence suggests that miRNAs are differentially expressed in the failing myocardium and play an important role in progression of heart failure by targeting genes that govern diverse functions in cardiac remodeling process including myocyte hypertrophy, excitation-contraction coupling, increased myocyte loss, and myocardial fibrosis. In addition to their role in adverse cardiac remodeling, miRNAs hold promise as biomarkers of disease progression in heart failure given their presence in circulation and enhanced stability. Further development of miR-based therapeutics may allow for modulation of cardiac and/or systemic levels of specific miRNAs in patients with heart failure . Here, we summarize current knowledge of miRNAs in relation to their role in regulating various aspects of the cardiac remodeling process and discuss their potential use as biomarkers and/or therapeutic targets in heart failure.
Authors:
Veli K Topkara; Douglas L Mann
Related Documents :
3184455 - Coronary aneurysms in a case of ehlers-danlos syndrome.
21903725 - Catheter-based left atrial appendage occlusion procedure: role of echocardiography.
11489775 - Predictors of outcome of biventricular repair in infants with multiple left heart obstr...
9989965 - Percutaneous mechanical mitral commissurotomy with a newly designed metallic valvulotom...
7296665 - Left atrial volume estimation by two-dimensional echocardiography.
8417695 - Clinical experience with ventricular assist systems in japan.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-23
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  -     ISSN:  1573-7241     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Center for Cardiovascular Research, Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Ave. Campus, PO Box 8066, St Louis, MO, 63110-1093, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal ca...
Next Document:  Cellular and RAS Changes in the Hearts of Young Obese Rats.