| Role of Macrophage Migration Inhibitory Factor in the Th2 Immune Response to Epicutaneous Sensitization. | |
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MedLine Citation:
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PMID: 21559932 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We examined the role of macrophage migration inhibitory factor (MIF) in the generation of the Th2 response using MIF-deficient mice in a model of epicutaneous sensitization to ovalbumin. Lymph node cells from sensitized MIF-deficient mice produce lower levels of Th2 cytokines after antigen challenge when compared to their wild-type counterparts. Sensitized mice lacking MIF show less pulmonary inflammation after intranasal antigen exposure. Mice deficient in CD74, the MIF receptor, also are unable to generate an inflammatory response to epicutaneous sensitization. Examination of the elicitation phase of the atopic response using DO11.10 OVA TCR transgenic animals shows that T cell proliferation and IL-2 production are strongly impaired in MIF-deficient T cells. This defect is most profound when both T cells and antigen-presenting cells are lacking MIF. These data suggest that MIF is crucial both for the sensitization and the elicitation phases of a Th2-type immune response in allergic disease. |
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Authors:
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Rituparna Das; Jeremy E Moss; Eve Robinson; Scott Roberts; Rebecca Levy; Yuka Mizue; Lin Leng; Courtney McDonald; Robert E Tigelaar; Christina A Herrick; Richard Bucala |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-11 |
Journal Detail:
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Title: Journal of clinical immunology Volume: - ISSN: 1573-2592 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Yale University School of Medicine, The Anlyan Center Room S525, 300 Cedar Street, New Haven, CT, 06520-8031, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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