Document Detail


The role of macrophage colony-stimulating factor in patients with acute myocardial infarction: a pilot study.
MedLine Citation:
PMID:  21642288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed whether macrophage colony-stimulating factor (M-CSF) levels are associated with left ventricular systolic dysfunction (LVSD) in patients with acute myocardial infarction (AMI). We studied 56 patients with AMI (mean age: 67 ± 12 years) and identified those with clinical (Killip class >II) or echocardiographic signs (ejection fraction ≤45%) of LVSD. We evaluated the established cardiovascular risk factors and measured several cardiovascular biomarkers, including M-CSF. Serum M-CSF concentrations (pg/mL) were significantly increased in patients with both clinical and echocardiographic signs of LVSD (460 ± 265 vs 290 ± 210, P = .0103 and 493 ± 299 vs 287 ± 174, P = .0028, respectively). We found a significant inverse association between M-CSF and ejection fraction (r = -.351, P = .0079). Logistic regression analysis revealed that, among all evaluated clinical and biochemical parameters, the stronger predictor of LVSD was M-CSF (odds ratios 2.1, 95% confidence interval 1.1-2.9, P = .0168). This is the first study reporting plasma M-CSF levels as independent determinants of low LV ejection fraction and clinical LV dysfunction in patients with AMI.
Authors:
Giuseppina Novo; Manfredi Rizzo; Salvatore La Carruba; Marco Caruso; Gisella Rita Amoroso; Carmela Rita Balistreri; Giuseppe Coppola; Giovanna Evola; Calogero Caruso; Pasquale Assennato; Salvatore Novo; Dario Mancuso
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Publication Detail:
Type:  Journal Article     Date:  2011-06-03
Journal Detail:
Title:  Angiology     Volume:  63     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-18     Completed Date:  2012-03-06     Revised Date:  2012-03-27    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-30     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Medical Specialties, University of Palermo, Via del Vespro 129, Palermo, Italy. novog@unipa.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Female
Humans
Macrophage Colony-Stimulating Factor / blood*
Male
Myocardial Infarction / blood*,  complications*
Pilot Projects
Predictive Value of Tests
Ventricular Dysfunction, Left / blood*,  etiology*
Chemical
Reg. No./Substance:
0/Biological Markers; 81627-83-0/Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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