| A role for the MS analysis of nucleic acids in the post-genomics age. | |
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MedLine Citation:
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PMID: 19897384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The advances of mass spectrometry in the analysis of nucleic acids have tracked very closely the exciting developments of instrumentation and ancillary technologies, which have taken place over the years. However, their diffusion in the broader life sciences community has been and will be linked to the ever evolving focus of biomedical research and its changing demands. Before the completion of the Human Genome Project, great emphasis was placed on sequencing technologies that could help accomplish this project of exceptional scale. After the publication of the human genome, the emphasis switched toward techniques dedicated to the exploration of sequences not coding for actual protein products, which amount to the vast majority of transcribed elements. The broad range of capabilities offered by mass spectrometry is rapidly advancing this platform to the forefront of the technologies employed for the structure-function investigation of these noncoding elements. Increasing focus on the characterization of functional assemblies and their specific interactions has prompted a re-evaluation of what has been traditionally construed as nucleic acid analysis by mass spectrometry. Inspired by the accelerating expansion of the broader field of nucleic acid research, new applications to fundamental biological studies and drug discovery will help redefine the evolving role of MS-analysis of nucleic acids in the post-genomics age. |
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Authors:
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Daniele Fabris |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-09-17 |
Journal Detail:
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Title: Journal of the American Society for Mass Spectrometry Volume: 21 ISSN: 1879-1123 ISO Abbreviation: J. Am. Soc. Mass Spectrom. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010412 Medline TA: J Am Soc Mass Spectrom Country: United States |
Other Details:
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Languages: eng Pagination: 1-13 Citation Subset: IM |
Copyright Information:
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2010. Published by Elsevier Inc. |
Affiliation:
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Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland 21228, USA. fabris@umbc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Genomics
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methods*,
trends Humans Mass Spectrometry / methods*, trends* Models, Molecular Nucleic Acid Conformation Nucleic Acids / chemistry*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01-GM643208/GM/NIGMS NIH HHS; R21-NS063871/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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