Document Detail


Role of the MMP9 Gene in Hemorrhagic Transformations After Tissue-Type Plasminogen Activator Treatment in Stroke Patients.
MedLine Citation:
PMID:  22496335     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Despite the benefits of tissue-type plasminogen activator treatment, some stroke patients experience adverse hemorrhagic transformations (HT). Plasma protein levels of MMP9 have been associated with HT occurrence. We aimed to analyze the association of the MMP9 gene with HT occurrence. METHODS: We analyzed the MMP9 gene in blood samples from 885 stroke patients treated with tissue-type plasminogen activator by tag-SNP, imputed SNP, direct sequencing, and RNA expression. RESULTS: We did not observe any significant association between MMP9 genetic variations or MMP9 expression and HT occurrence. Moreover, no association was found between MMP9 expression and MMP9 polymorphisms. CONCLUSIONS: Genetic variations in the MMP9 gene are not associated with HT occurrence in tissue-type plasminogen activator-treated patients.
Authors:
Israel Fernández-Cadenas; Alberto Del Río-Espínola; Caty Carrera; Sophie Domingues-Montanari; Maite Mendióroz; Pilar Delgado; Anna Rosell; Marc Ribó; Dolors Giralt; Manolo Quintana; Mar Castellanos; Victor Obach; Sergi Martínez; Mari Mar Freijo; Jordi Jiménez-Conde; Jaume Roquer; Joan Martí-Fábregas; Carlos A Molina; José Alvarez-Sabín; Joan Montaner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-10
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  -     ISSN:  1524-4628     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Neurovascular Research Laboratory and Neurology Unit, Vall d'Hebron Hospital. Departamento de Medicina, UAB, Vall d'Hebron Research Institute; Department of Neurology, Hospital Universitari Dr Josep Trueta, Institut d'Investigació Biomèdica de Girona; Stroke Unit, Department of Neurological Sciences, Hospital Clínic and Institut d' Investigacions Biomédiques August Pi i Sunyer, University of Barcelona; Department of Neurology, Hospital de la Santa Creu i Sant Pau; Department of Neurology, Hospital de Basurto; Department of Neurology, Hospital del Mar, Parc de Salut Mar-IMIM, Barcelona and Universitat Autònoma de Barcelona. Neurovascular Research Group.
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