Document Detail


The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report.
MedLine Citation:
PMID:  23614695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Study of the human lung microbiome in the context of pulmonary health and disease is an area of emerging research interest that is being driven by several contributing factors. These factors include increased recognition of the diversity of human-associated microbiota, their roles in health and in diseases associated with chronic inflammation, and advancements in technologies and tools that have facilitated such discoveries about the microbiota in organ systems outside of the lung. Therefore, the overarching goals of lung microbiome research are: to identify and characterize microbial populations associated with the respiratory tract and lungs; to understand their roles in lung health and disease; and, we hope, to allow the development of improved approaches for diagnosing and treating chronic respiratory diseases in which the microbiome has a role. Recent studies of the lung microbiome have yielded a number of interesting findings but also highlighted questions and challenges for researchers and clinicians. In December 2011, the National Heart, Lung, and Blood Institute convened a workshop to identify key issues and areas for further attention or development to advance research on the lung microbiome. Current knowledge and the state of research on the lung and related areas of human microbiome investigation were reviewed and discussed.
Authors:
Yvonne J Huang; Emily S Charlson; Ronald G Collman; Sandra Colombini-Hatch; Fernando D Martinez; Robert M Senior
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  187     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-17     Completed Date:  2013-08-19     Revised Date:  2013-08-19    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1382-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Biomedical Research
Education
Humans
Intestines / microbiology
Lung / microbiology*
Lung Diseases / microbiology*
Metagenome*
Practice Guidelines as Topic
Grant Support
ID/Acronym/Agency:
K23 HL105572/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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