| The Role of Lipoprotein-Associated Phospholipase A(2) as a Marker and Potential Therapeutic Target in Atherosclerosis. | |
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MedLine Citation:
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PMID: 21207201 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that generates inflammatory mediators within atherosclerotic plaques. In epidemiologic studies there is an association between higher plasma Lp-PLA(2) activity and myocardial infarction, stroke and cardiovascular mortality. In animal models, darapladib, a specific inhibitor of Lp-PLA(2,) decreases the size of the atheroma necrotic core and plaques with thin fibrous caps. Early clinical trials suggest darapladib effectively and safely inhibits Lp-PLA(2) activity both in plasma and in carotid atheroma. Two large phase III clinical trials that are currently in progress will determine whether darapladib will reduce the risk of myocardial infarction, stroke, and cardiovascular death by stabilizing atherosclerotic plaques. |
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Authors:
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Ralph A H Stewart; Harvey D White |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-5 |
Journal Detail:
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Title: Current atherosclerosis reports Volume: - ISSN: 1534-6242 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Green Lane Cardiovascular Service, Auckland City Hospital, Private Bag 92024, Auckland, 1030, New Zealand, RStewart@adhb.govt.nz. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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