| The role of lipid transfer proteins in allergic diseases. | |
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MedLine Citation:
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PMID: 20582490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonspecific lipid transfer proteins (LTPs) are important allergens in fruits, vegetables, nuts, pollen, and latex. Despite their wide distribution throughout the plant kingdom, their clinical relevance is largely confined to the Mediterranean area. As they can sensitize via the gastrointestinal tract, LPTs are considered true food allergens, and IgE reactivity to LTPs is often associated with severe systemic symptoms. Although Pru p 3 represents the predominant LTP in terms of patients' IgE recognition, the contribution of pollen LTPs in primary sensitization cannot be ruled out. Due to structural homology, LTPs from different allergen sources are generally IgE cross-reactive. However, sensitization profiles among allergic patients are extremely heterogeneous, and individual cross-reactivity patterns can be restricted to a single LTP or encompass many different LTPs. Molecule-based approaches in allergy research and diagnosis are important for better understanding of LTP allergy and could assist clinicians with providing adequate patient-tailored advice. |
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Authors:
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Matthias Egger; Michael Hauser; Adriano Mari; Fatima Ferreira; Gabriele Gadermaier |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current allergy and asthma reports Volume: 10 ISSN: 1534-6315 ISO Abbreviation: Curr Allergy Asthma Rep Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101096440 Medline TA: Curr Allergy Asthma Rep Country: United States |
Other Details:
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Languages: eng Pagination: 326-35 Citation Subset: IM |
Affiliation:
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Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, Austria. matthias.egger@sbg.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Antigens, Plant / chemistry*, immunology* Carrier Proteins / chemistry*, genetics, immunology* Cross Reactions Diet, Mediterranean / adverse effects Epitopes, T-Lymphocyte / immunology Food Hypersensitivity / immunology* Humans Immunoglobulin E / immunology Mediterranean Region Models, Molecular Molecular Sequence Data Oryza sativa / chemistry Plants / adverse effects Pollen / immunology Sequence Alignment |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Plant; 0/Carrier Proteins; 0/Epitopes, T-Lymphocyte; 0/Ltp1 protein, barley; 0/lipid transfer protein; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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