Document Detail

Role of Lipid Components in Formation and Reactivation of Mycobacterium smegmatis "Nonculturable" Cells.
MedLine Citation:
PMID:  21639843     Owner:  NLM     Status:  In-Data-Review    
We have found that transition of actively dividing Mycobacterium smegmatis cells into the dormant "nonculturable" state is accompanied by increase in the protein/lipid ratio and disappearance of one of the main lipid components of the mycobacterial cells, trehalose monomycolate. In this case, oleic acid is accumulated in the culture medium due to its secretion by the mycobacterial cells. Addition of lipids of different classes to "nonculturable" M. smegmatis cells induces their resuscitation. The lipid reactivating effect is evidently caused by the presence of fatty acids in their composition, because free fatty acids also exhibited reactivation effect. Oleic acid in concentration of 0.05-3 μg/ml exhibited maximal effect, and that allows us to draw a conclusion concerning its signal role in the transition of dormant cells into active state.
E V Nazarova; M O Shleeva; N S Morozova; Yu K Kudykina; G N Vostroknutova; A O Ruzhitsky; A A Selishcheva; G M Sorokoumova; V I Shvets; A S Kaprelyants
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry. Biokhimii͡a     Volume:  76     ISSN:  1608-3040     ISO Abbreviation:  Biochemistry Mosc.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376536     Medline TA:  Biochemistry (Mosc)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  636-44     Citation Subset:  IM    
Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia.
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