Document Detail


The role of the kallikrein-kinin system genes in the salt sensitivity of blood pressure: the GenSalt Study.
MedLine Citation:
PMID:  23035147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The current study comprehensively examined the association between common genetic variants of the kallikrein-kinin system (KKS) and blood pressure salt sensitivity. A 7-day low-sodium followed by a 7-day high-sodium dietary intervention was conducted among 1,906 Han Chinese participants recruited from 2003 to 2005. Blood pressure was measured by using a random-zero sphygmomanometer through the study. A total of 205 single nucleotide polymorphisms (SNPs) covering 11 genes of the KKS were selected for the analyses. Genetic variants of the bradykinin receptor B2 gene (BDKRB2) and the endothelin converting enzyme 1 gene (ECE1) showed significant associations with the salt-sensitivity phenotypes even after adjustment for multiple testing. Compared with the major G allele, the BDKRB2 rs11847625 minor C allele was significantly associated with increased systolic blood pressure responses to low-sodium intervention (P = 0.0001). Furthermore, a haplotype containing allele C was associated with an increased systolic blood pressure response to high-sodium intervention (P = 0.0009). Seven highly correlated ECE1 SNPs were shown to increase the diastolic blood pressure response to low-sodium intervention (P values ranged from 0.0003 to 0.002), with 2 haplotypes containing these 7 SNPs also associated with this same phenotype (P values ranged from 0.0004 to 0.002). In summary, genetic variants of the genes involved in the regulation of KKS may contribute to the salt sensitivity of blood pressure.
Authors:
Dongfeng Gu; Qi Zhao; Tanika N Kelly; James E Hixson; Dabeeru C Rao; Jie Cao; Jing Chen; Jianxin Li; Jichun Chen; Xu Ji; Dongsheng Hu; Xushan Wang; De-Pei Liu; Jiang He
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of epidemiology     Volume:  176 Suppl 7     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  2012-12-17     Revised Date:  2013-10-09    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S72-80     Citation Subset:  IM    
Affiliation:
Department of Evidence Based Medicine, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China. gudf@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Aspartic Acid Endopeptidases / genetics
Blood Pressure / drug effects,  genetics*
China
Diet, Sodium-Restricted
Female
Genotype
Haplotypes
Humans
Kallikrein-Kinin System / drug effects,  genetics*
Male
Metalloendopeptidases / genetics
Polymorphism, Single Nucleotide / genetics
Receptor, Bradykinin B2 / genetics
Sodium, Dietary / pharmacology*
Grant Support
ID/Acronym/Agency:
R01HL087263/HL/NHLBI NIH HHS; R01HL090682/HL/NHLBI NIH HHS; U01HL072507/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptor, Bradykinin B2; 0/Sodium, Dietary; EC 3.4.23.-/Aspartic Acid Endopeptidases; EC 3.4.24.-/Metalloendopeptidases; EC 3.4.24.71/endothelin-converting enzyme
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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