| Role of KATP channels in sepsis. | |
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MedLine Citation:
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PMID: 16963005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sepsis is an infection-induced inflammatory syndrome responsible for approximately 10% of all deaths worldwide. While pathophysiological mechanisms remain to be fully unravelled, new insights and discoveries are yielding significant improvements in outcome, particularly in the high mortality conditions of shock and multi-organ failure. One potential target is the ATP-sensitive potassium (K(ATP)) channel, an ion channel critical to the cardiovascular stress response. Excessive activation of the vascular channel is now recognised as a major cause of hypotension and vascular hyporesponsiveness to catecholamines in septic shock. Some researchers advocate therapeutic blockade of these channels; however, outside the vasculature, channel opening may actually represent a protective mechanism against cellular damage. In this review we critically examine the role of the K(ATP) channel in sepsis. |
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Authors:
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James F Buckley; Mervyn Singer; Lucie H Clapp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-07-21 |
Journal Detail:
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Title: Cardiovascular research Volume: 72 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-18 Completed Date: 2007-02-09 Revised Date: 2013-04-29 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 220-30 Citation Subset: IM |
Affiliation:
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British Heart Foundation Laboratories and Bloomsbury Institute for Intensive Care Medicine, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism* Humans Ischemic Preconditioning Multiple Organ Failure / metabolism* Potassium Channels / metabolism* Sepsis / metabolism* Vasodilation |
| Grant Support | |
ID/Acronym/Agency:
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FS/02/068/14402//British Heart Foundation; G117/440//Medical Research Council; G117/440(77598)//Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels; 56-65-5/Adenosine Triphosphate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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