Document Detail

Role of KATP channels in repetitive induction of ventricular fibrillation.
MedLine Citation:
PMID:  17255149     Owner:  NLM     Status:  MEDLINE    
AIM: Patients with sustained ventricular tachyarrhythmias are at high risk for sudden cardiac death. The mechanisms leading to multiple temporally related episodes of ventricular fibrillation (VF) are not yet fully elucidated, and treatment options are limited. We investigated whether K(ATP)-channels could be involved in triggering VF.
METHODS: We determined postarrhythmic changes of monophasic action potentials (MAP) after repetitive induction of VF in 32 Langendorff-perfused rabbit hearts.
RESULTS: Postarrhythmic action potential duration (APD) was significantly shorter compared with baseline (100 +/- 12 ms vs. 140 +/- 8 ms, P < 0.05). With increasing numbers of VF and shortening of recovery intervals between VF episodes (2 min) inducibility of VF increased, and abbreviation of APD became more prominent (90 +/- 5 ms vs. 130 +/- 4 ms, P < 0.05). Pre-treatment with the selective K(ATP) blocking agent HMR 1883 led to a significant increase of postarrhythmic APDs compared with control hearts (100 +/- 12 ms vs. 118 +/- 3 ms, P = 0.0013). Moreover, HMR 1883 significantly reduced inducibility of VF and increased the rate of successful defibrillation.
CONCLUSIONS: Repetitive episodes of VF result in postarrhythmic abbreviation of APDs, a phenomenon thought to be of potential relevance for incessant tachyarrhythmias in patients. Prevention of postarrhythmic MAP-shortening by HMR 1883 might be useful in suppressing VF.
Alexander Bauer; Ruediger Becker; Jens Dreyhaupt; Frederik Voss; Patricia Kraft; Kamilla Kelemen; Julia C Senges-Becker; Hugo A Katus; Wolfgang Schoels
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2007-01-25
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  9     ISSN:  1099-5129     ISO Abbreviation:  Europace     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-08     Completed Date:  2007-08-01     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  IM    
Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany.
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MeSH Terms
Action Potentials / physiology
Cardiac Pacing, Artificial
Disease Models, Animal
Potassium Channel Blockers / pharmacology
Potassium Channels / drug effects,  physiology*
Sulfonamides / pharmacology
Thiourea / analogs & derivatives,  pharmacology
Ventricular Fibrillation / etiology*,  physiopathology,  therapy*
Reg. No./Substance:
0/Potassium Channel Blockers; 0/Potassium Channels; 0/Sulfonamides; 0/mitochondrial K(ATP) channel; 62-56-6/Thiourea; 94301K998R/clamikalant

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