Document Detail

Role of interleukin-6 as an early marker of fat embolism syndrome: a clinical study.
MedLine Citation:
PMID:  23423626     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A few animal studies have shown that IL-6 can serve as an early marker of fat embolism syndrome. The degree to which this is true in human trauma victims is unknown.
QUESTIONS/PURPOSES: In this clinical study, we sought to determine (1) whether elevated serum IL-6 levels at 6, 12, and 24 hours in patients with skeletal trauma were associated with the development of fat embolism syndrome (FES) within 72 hours after injury, and (2) at what time after trauma peak IL-6 levels are observed.
METHODS: Forty-eight patients between 16 and 40 years old who presented to our tertiary trauma center within 6 hours of injury with long bone and/or pelvic fractures were included in this study. Serum IL-6 levels were measured at 6, 12, and 24 hours after injury. The patients were observed clinically and monitored for 72 hours for development of FES symptoms. Gurd's criteria were used to diagnose FES.
RESULTS: Elevated serum IL-6 levels 12 hours after trauma correlated with an increased likelihood of having FES develop; no significant relationship was observed between IL-6 levels at 6 or 24 hours and the development of FES. Patients with FES had a mean IL-6 level of 131 pg/mL, whereas those without FES had a mean IL-6 level of 72 pg/mL. Peak IL-6 levels were observed at 12 hours.
CONCLUSIONS: An elevated serum IL-6 level may be useful as an early marker of FES in patients with isolated skeletal trauma.
LEVEL OF EVIDENCE: Level II, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.
Shiva Prakash; Ramesh Kumar Sen; Sujit Kumar Tripathy; Indu Mohini Sen; R R Sharma; Sadhna Sharma
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Publication Detail:
Type:  Journal Article     Date:  2013-02-20
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  471     ISSN:  1528-1132     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-10     Completed Date:  2013-08-28     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2340-6     Citation Subset:  AIM; IM    
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MeSH Terms
Biological Markers / blood
Dislocations / complications,  diagnosis
Early Diagnosis
Embolism, Fat / blood,  diagnosis*,  immunology
Fractures, Bone / complications*,  diagnosis
Injury Severity Score
Interleukin-6 / blood*
Predictive Value of Tests
Prospective Studies
Tertiary Care Centers
Time Factors
Trauma Centers
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/IL6 protein, human; 0/Interleukin-6
Comment In:
Clin Orthop Relat Res. 2013 Jul;471(7):2347-8   [PMID:  23572348 ]

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