| The Role of Innate Immunity in the Host Defense Against Intestinal Bacterial Pathogens. | |
| | |
MedLine Citation:
|
PMID: 22139594 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Eradication of infectious disease is our global health challenge. After encountering intestinal infection with a bacterial pathogen, the host defense program is initiated by local antigen-presenting cells (APCs) that eliminate invading pathogens by phagocytosis and establish localized inflammation by secreting cytokines and chemokines. These pathogen-experienced APCs migrate to the mesenteric lymph nodes, where host immune responses are precisely orchestrated. Initiation and regulation of this defense program appear to be largely dependent on innate immunity which is antigen non-specific and provides a rapid defense against broader targets. On the other hand, many bacterial enteropathogens have evoked abilities to modify the host defense program to their advantage. Therefore, better understanding of the host-pathogen interactions is essential to establish effective eradication strategies for enteric infectious diseases. In this review, we will discuss the current understanding of innate immune regulation of the host defense mechanisms against intestinal infection by bacterial pathogens. |
| | |
Authors:
|
John Sotolongo; Jose Ruiz; Masayuki Fukata |
Related Documents
:
|
21911344 - Sodium butyrate inhibits pathogenic yeast growth and enhances the functions of macropha... 6980134 - Granulopoiesis and colony stimulating factor production in regenerating liver. 8288874 - Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood... 7509214 - Production of hematopoietic stem cell-chemotactic factor by bone marrow stromal cells. 8609714 - Cd49f (alpha 6 integrin) and cd66a (bgp) are specifically induced by retinoids during h... 21421874 - Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-6 |
Journal Detail:
|
Title: Current infectious disease reports Volume: - ISSN: 1534-3146 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888983 Medline TA: Curr Infect Dis Rep Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Post Office Box 016960 (D-149), Miami, FL, 33101, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A case of mistaken identity: HSPs are no DAMPs but DAMPERs.
Next Document: CE and CEC analysis of phytochemicals in herbal medicines.