| Role of the Inflammatory Protein Serine Protease Inhibitor Kazal in Preventing Cytolytic Granule Granzyme A-Mediated Apoptosis. | |
| | |
MedLine Citation:
|
PMID: 22043941 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Serine protease inhibitor Kazal (SPIK) is an inflammatory protein whose levels are elevated in numerous cancers. However, the role of this protein in cancer development is unknown. We have recently found that SPIK suppresses serine protease-dependent cell apoptosis. Here, we report that anti-SPIK antibodies can co-immmuneprecipitate serine protease granzyme A (GzmA), a cytolytic granule secreted by cytotoxic T-lymphocyte and natural killer cells during immunesurveillance, and that SPIK suppresses GzmA-induced cell apoptosis. Deletion studies show that the C3-C4 region of SPIK is critical for this suppression. These studies suggest that overexpression of SPIK may prevent GzmA-mediated immune-killing, thereby establishing the tolerance of cancer cells to the body's immunesurveillance system. Suppression of overexpressed SPIK can restore the susceptibility of these cells to apoptotic death triggered by GzmA. This finding implies that it is possible to overcome tolerance of cancer cells to the body's immunesurveillance system and restore the GzmA-mediated immune-killing by suppressing the over-expression of SPIK. |
| | |
Authors:
|
Felix Lu; Jason Lamontagne; Angela Sun; Mark Pinkerton; Timothy Block; Xuanyong Lu |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-17 |
Journal Detail:
|
Title: Immunology Volume: - ISSN: 1365-2567 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-11-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0374672 Medline TA: Immunology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Journal compilation © 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Institute for Hepatitis and Virus Research, Doylestown, PA 18902. Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, College of Medicine, Drexel University, Doylestown, PA 18902. Davenport College, Yale University, New Haven, CT, 06511 Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129 Microbiology Department, University of Oklahoma, Norman OK, 73019. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fabrication of Reversible Poly(dimethylsiloxane) Surfaces via Host-Guest Chemistry and Their Repeate...
Next Document: Controlling the Wettability of Hierarchically Structured Thermoplastics.