Document Detail


The Role of Inflammation and Infection in Preterm Birth.
MedLine Citation:
PMID:  21890015     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Much emphasis in recent decades has been devoted to inflammation and infection as a premier causal mechanism of preterm birth. This article explores the epidemiologic, clinical, and animal data that exist to support this conceptual paradigm as well as proposed mechanisms through which to potentially mitigate the adversity of prematurity. Truly successful interventions are not likely to occur until the pathogenesis of preterm birth and the role of inflammation in causing not only parturition but also fetal and neonatal injury is fully elucidated.
Authors:
Jamie A Bastek; Luis M Gómez; Michal A Elovitz
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Publication Detail:
Type:  Journal Article     Date:  2011-07-20
Journal Detail:
Title:  Clinics in perinatology     Volume:  38     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  385-406     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Maternal and Child Health Research Program, Philadelphia, PA, USA; Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA, USA; Department of Maternal-Fetal Medicine, 3400 Spruce Street, 2000 Courtyard Building, Philadelphia, PA 19104, USA.
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