Document Detail


Role of impaired central tolerance to α-myosin in inflammatory heart disease.
MedLine Citation:
PMID:  22902177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For more than a half century, autoimmunity has been linked to a diverse array of heart diseases, including rheumatic carditis, myocarditis, Chagas' cardiomyopathy, post-myocardial infarction (Dressler's) syndrome, and idiopathic dilated cardiomyopathy. Why the heart is targeted by autoimmunity in these seemingly unrelated conditions has remained enigmatic. Here, we discuss our recent studies indicating that this susceptibility is mediated by impaired negative selection of autoreactive α-myosin heavy-chain-specific CD4(+) T cells in the thymus of both mice and humans. We describe how this process may place the heart at increased risk for autoimmune attack following ischemic or infectious injury, providing a rationale for the development of antigen-specific tolerogenic therapies.
Authors:
HuiJuan Lv; Myra A Lipes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-16
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  22     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-03-11     Revised Date:  2013-08-20    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Section on Immunobiology at the Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmunity*
Biological Markers / blood
CD4-Positive T-Lymphocytes / immunology*
Cardiomyopathy, Dilated / immunology
Central Tolerance / immunology*
Chagas Cardiomyopathy / immunology
Heart Diseases / immunology*
Humans
Inflammation / immunology
Myocardial Infarction / immunology
Myocarditis / immunology
Rheumatic Heart Disease / immunology
Risk Assessment
Risk Factors
Thymus Gland / immunology
Ventricular Myosins / immunology*
Grant Support
ID/Acronym/Agency:
P30 DK036836/DK/NIDDK NIH HHS; R01 DK072090/DK/NIDDK NIH HHS; R01 HL077554/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; EC 3.6.1.-/Ventricular Myosins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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