| The role of the IL-12 cytokine family in directing T-cell responses in oral candidosis. | |
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MedLine Citation:
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PMID: 20981280 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Candida albicans is an opportunistic fungal pathogen that normally exists as a harmless commensal in humans. In instances where host debilitation occurs, Candida can cause a range of clinical infections, and whilst these are primarily superficial, effecting mucosal membranes, systemic infections can develop in severely immunocompromised individuals. The mechanism of host immunity during commensal carriage of C. albicans has been intensively studied. In this paper, we present the most recent information concerning host recognition of C. albicans leading to cytokine production and the subsequent T-cell responses generated in response to C. albicans. Particular focus is given to the role of the IL-12 cytokine family including IL-12, IL-23, IL-27, and IL-35, in host immunity to Candida. CD4(+) T-cells are considered crucial in the regulation of immunity and inflammation. In this regard, the role of Th1/2, helper cells, together with the recently identified Th17 and Treg cells in candidosis will be discussed. Understanding the detailed mechanisms that underlie host immunity to Candida not only will be of benefit in terms of the infections caused by this organism but could also be exploited in the development of therapeutic interventions for other diseases. |
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Authors:
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Xiao-Qing Wei; Helen Rogers; Michael A O Lewis; David W Williams |
Publication Detail:
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Type: Journal Article; Review Date: 2010-10-24 |
Journal Detail:
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Title: Clinical & developmental immunology Volume: 2011 ISSN: 1740-2530 ISO Abbreviation: Clin. Dev. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2010-10-28 Completed Date: 2011-05-24 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101183692 Medline TA: Clin Dev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 697340 Citation Subset: IM |
Affiliation:
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Cardiff University, Heath Park, UK. weix1@cardiff.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Candidiasis, Oral / immunology* Host-Pathogen Interactions Humans Immunity, Cellular* Immunomodulation Interleukin-12 / genetics, immunology* Mice Multigene Family / immunology Receptors, Pattern Recognition / immunology* T-Lymphocytes / immunology* Th1-Th2 Balance |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Pattern Recognition; 187348-17-0/Interleukin-12 |
| Comments/Corrections | |
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