Document Detail


Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients.
MedLine Citation:
PMID:  20191078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intercellular adhesion molecule-1 (ICAM-1) and E-selectin have been shown to predict cardiovascular disease (CVD) such as myocardial infarction, stroke, and peripheral arterial occlusive disease (PAOD).
METHODS: Two mutations, S128R in E-selectin and K469E in ICAM-1, were investigated in 156 patients with PAOD and 100 control subjects using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in an Egyptian population.
RESULTS: The distribution of E-selectin genotypes in patients affected by PAOD was 84.6% for the AA genotype and 15.4% for the AC genotype. In the control arm the distribution was 97% for the AA genotype and 3% for the AC genotype. There was a statistically significance difference in the distribution of the AC genotype in PAOD patients when compared with the control subjects. Additionally, the distribution of ICAM-1 genotypes in patients affected by PAOD was 30.8% with the EE, 48% with the EK, and 21.2% with the KK genotypes. The distribution of ICAM-1 genotypes in control subjects was 13% EE, 33% EK and 54% KK. The EE genotype was significantly more common in PAOD patients than in the controls.
CONCLUSION: S128R and K469E polymorphisms were associated with increased risk in PAOD. Early detection of these polymorphic genes helps in early prophylaxis against PAOD.
Authors:
Olfat Shaker; Amr Zahra; Ahmed Sayed; Ayman Refaat; Zakaria El-Khaiat; Gehan Hegazy; Khaled El-Hindawi; Mohamed Ay-El Deen
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2010-02-04
Journal Detail:
Title:  Vascular health and risk management     Volume:  6     ISSN:  1178-2048     ISO Abbreviation:  Vasc Health Risk Manag     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-01     Completed Date:  2011-01-27     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101273479     Medline TA:  Vasc Health Risk Manag     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
Affiliation:
Department of Medical Biochemistry, Cairo University, Cairo, Egypt. olfatshaker@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Alleles
Arterial Occlusive Diseases / genetics*
Blood Chemical Analysis
Case-Control Studies
Diabetes Complications / genetics
E-Selectin / genetics*
Egypt / epidemiology
Female
Genotype
Humans
Intercellular Adhesion Molecule-1 / genetics*
Male
Middle Aged
Myocardial Infarction / genetics*
Peripheral Arterial Disease / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic*
Risk Factors
Chemical
Reg. No./Substance:
0/E-Selectin; 126547-89-5/Intercellular Adhesion Molecule-1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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