| The Role of the Host Defense System in the Development of Cerebral Vasospasm: Analogies between Atherosclerosis and Subarachnoid Hemorrhage. | |
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MedLine Citation:
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PMID: 23095669 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Similar to atherosclerosis, platelet-derived growth factor (PDGF)-BB, a major growth factor for vascular smooth muscle cells, is produced in arterial walls to repair arteries after subarachnoid hemorrhage (SAH). On review of a series of research articles that focus on defensive host responses to SAH, PDGF-BB is identified as a spasmogen, based on the following findings: (1) foreign substances injected into the subarachnoid space cause persistent constriction of cerebral arteries with a time course and histological features almost identical to those seen after SAH; (2) persistent constriction induced by SAH or a foreign substance is dependent on the complement system; (3) the complement system, which stimulates platelets, macrophages and endothelial cells to secrete PDGF-BB, is activated in both the cerebrospinal fluid (CSF) and plasma immediately after SAH; (4) PDGF-BB levels in the CSF are significantly elevated in patients with delayed cerebral ischemia; (5) the immunodensity of PDGF-BB in the arterial walls correlates well with the severity of cerebral vasospasm; (6) intracisternal injection of PDGF-BB induces persistent constriction of cerebral arteries in a dose-dependent manner; (7) prolonged contact with blood clots promotes the contractile response of cerebral arteries to PDGF-BB, and (8) administration of an antagonist of PDGF-BB function suppresses the development of cerebral vasospasm. |
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Authors:
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Hiroji Yanamoto; Hiroharu Kataoka; Yukako Nakajo; Koji Iihara |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-24 |
Journal Detail:
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Title: European neurology Volume: 68 ISSN: 1421-9913 ISO Abbreviation: Eur. Neurol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: - |
Other Details:
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Languages: ENG Pagination: 329-343 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Laboratory of Neurology and Neurosurgery, National Cerebral and Cardiovascular Research Center, Suita, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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