Document Detail

The Role of Hepatic Liver X Receptor α- and Sterol Regulatory Element Binding Protein-1c-mediated Lipid Disorder in the Pathogenesis of Non-alcoholic Steatohepatitis in Rats.
MedLine Citation:
PMID:  21986124     Owner:  NLM     Status:  In-Data-Review    
Liver X receptor α (LXRα) and sterol regulatory element binding protein-1c (SREBP-1c) were studied in rats with non-alcoholic steatohepatitis (NASH) induced by a high-fat diet. Forty 5-week-old rats were fed either a high-fat diet (n = 30) or a normal diet (n = 10) for 9, 13 or 17 weeks. The mRNA and protein levels for LXRα and SREBP-1c were measured at each time point, as was fatty acid synthase (FAS) activity and the serum levels of free fatty acid (FFA) and triglyceride (TG). The mRNA and protein levels for LXRα and SREBP-1c, FAS activity and serum levels of FFA and TG all significantly increased from week 9 in the high-fat diet rats versus controls. In conclusion, a high-fat diet upregulates LXRα which, in turn, upregulates SREBP-1c, increasing the activity of FAS and FFA and accumulation of TG in hepatocytes. Thus, LXRα and SREBP-1c contribute to the development of NASH.
Z-L Ai; C-H Zhu; M Min; J Wang; C-H Lan; L-L Fan; W-J Sun; D-F Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  39     ISSN:  1473-2300     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1219-29     Citation Subset:  IM    
Department of Gastroenterology and Hepatology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.
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