| The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment. | |
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MedLine Citation:
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PMID: 20439455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hedgehog (Hh) signaling pathway plays an important role in embryogenesis across multiple species. Its activity is reduced or absent in adult organisms. However, activation of the pathway has been shown to be a factor in the development of a number of human malignancies and inhibition of the pathway is being investigated as a potential treatment for multiple cancers. The most extensively investigated and best characterized is basal cell carcinoma (BCC), which occurs in both an inherited form (basal cell nevus syndrome or Gorlin's syndrome) and a sporadic form. Sporadic BCCs are the most common human malignancy. There is recent data available on the use of a small molecule inhibitor of the pathway in BCC. |
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Authors:
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Ivor Caro; Jennifer A Low |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-05-03 |
Journal Detail:
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Title: Clinical cancer research : an official journal of the American Association for Cancer Research Volume: 16 ISSN: 1078-0432 ISO Abbreviation: Clin. Cancer Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-02 Completed Date: 2010-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502500 Medline TA: Clin Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 3335-9 Citation Subset: IM |
Affiliation:
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Genentech BioOncology, 1 DNA Way, South San Francisco, California 94080, USA. icaro@gene.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Basal Cell Nevus Syndrome
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metabolism Carcinoma, Basal Cell / metabolism* Hedgehog Proteins / metabolism*, physiology Humans Ligands Receptors, G-Protein-Coupled / metabolism Signal Transduction Skin Neoplasms / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Hedgehog Proteins; 0/Ligands; 0/Receptors, G-Protein-Coupled; 0/SMO protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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