Document Detail

The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment.
MedLine Citation:
PMID:  20439455     Owner:  NLM     Status:  MEDLINE    
The hedgehog (Hh) signaling pathway plays an important role in embryogenesis across multiple species. Its activity is reduced or absent in adult organisms. However, activation of the pathway has been shown to be a factor in the development of a number of human malignancies and inhibition of the pathway is being investigated as a potential treatment for multiple cancers. The most extensively investigated and best characterized is basal cell carcinoma (BCC), which occurs in both an inherited form (basal cell nevus syndrome or Gorlin's syndrome) and a sporadic form. Sporadic BCCs are the most common human malignancy. There is recent data available on the use of a small molecule inhibitor of the pathway in BCC.
Ivor Caro; Jennifer A Low
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-05-03
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  16     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3335-9     Citation Subset:  IM    
Genentech BioOncology, 1 DNA Way, South San Francisco, California 94080, USA.
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MeSH Terms
Basal Cell Nevus Syndrome / metabolism
Carcinoma, Basal Cell / metabolism*
Hedgehog Proteins / metabolism*,  physiology
Receptors, G-Protein-Coupled / metabolism
Signal Transduction
Skin Neoplasms / metabolism*
Reg. No./Substance:
0/Hedgehog Proteins; 0/Ligands; 0/Receptors, G-Protein-Coupled; 0/SMO protein, human

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