| Role of HSPs and telomerase in radiotherapy. | |
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MedLine Citation:
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PMID: 16338850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inability of radiotherapy to control tumour growth is still a daunting clinical problem leading to failure of the overall treatment regimens. The fundamental question is; could tumour cells be specifically sensitized to ionizing radiation (IR) by heat or factors exclusively expressed in tumour cells? One such factor, expressed in most tumours and silent in somatic cells, is telomerase. Biochemical and genetic studies have established an association between telomere maintenance and extended life span of human cells mediated through the expression of the catalytic sub-unit of telomerase (hTERT). Because of this, telomerase is an attractive target for inhibition in anti-cancer therapy. Telomeres are maintained by telomerase and hTERT interacts with heat shock protein (HSP) chaperones. This review will focus on the possible role of HSPs and telomerase in sensitizing tumour cells and, thus, enhancing the potential of targeted radiotherapy. |
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Authors:
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Tej K Pandita |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group Volume: 21 ISSN: 0265-6736 ISO Abbreviation: Int J Hyperthermia Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-01-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8508395 Medline TA: Int J Hyperthermia Country: England |
Other Details:
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Languages: eng Pagination: 689-94 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line DNA Repair HSP70 Heat-Shock Proteins / genetics, metabolism* Humans Neoplasms / metabolism, radiotherapy* Radiotherapy* Telomerase / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA10445/CA/NCI NIH HHS; NS34746/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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