| Role of Growth Hormone, Glutamine and Enteral Nutrition in Pediatric Short Bowel Syndrome: A Pilot Follow-Up Study. | |
| | |
MedLine Citation:
|
PMID: 22161076 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: Aim of the study was to evaluate whether growth hormone (GH), glutamine (Gln), and enteral nutrition (EN) have a positive effect on intestinal adaptation in pediatric patients with short bowel syndrome (SBS). METHOD: 7 pediatric patients with SBS (small bowel remnant length: 60.57±15.18 cm; mean±SEM) were treated with GH (0.05 mg/kg/day), supplemental Gln (0.45 g/kg/day), plus EN for 3 weeks. After 3 weeks of treatment, GH was discontinued, and patients were maintained on Gln and EN or additionally received a high-carbohydrate-low-fat diet. Repeat treatment was given at regular intervals. Changes in weight and height increase, intestinal absorptive capacity and blood indices were evaluated. RESULT: All patients completed the treatment. The intestinal absorptive capacity and plasma levels of proteins were significantly improved after treatment. There were no major adverse effects in any patient and no death occurred. Growth velocity was also well maintained on follow-up. 6 patients were weaned off PN and lived on HCLF diet supplement with EN, while the last patient required less volume of PN. CONCLUSION: Multiple treatment approaches with GH, Gln, and EN at an early stage significantly improved intestinal adaptation in pediatric patients with SBS. Furthermore, the positive effect appeared to be sustained even after GH was discontinued. |
| | |
Authors:
|
M Guo; Y Li; J Li |
Related Documents
:
|
7499046 - Tonsillectomy and adenoidectomy in patients with down syndrome. 8071636 - Management of childhood asthma: more than juggling medication doses. 19516916 - Beta-blockers and health-related quality of life in patients with peripheral arterial d... 21170956 - Localization of cerebral functional deficits in patients with non-neuropsychiatric syst... 21683226 - The utility of routine pouchogram before ileostomy reversal in children and adolescents... 2662746 - Percutaneous catheter closure of the ductus arteriosus in children and young adults. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
|
Title: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie Volume: - ISSN: 1439-359X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105263 Medline TA: Eur J Pediatr Surg Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
|
Department of Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Liver Transplantation in Children with Cystic Fibrosis: Experience in our Centre and Preliminary Res...
Next Document: Continuation of vitamin K antagonists as acceptable anticoagulation regimen in patients undergoing p...