Document Detail


Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection.
MedLine Citation:
PMID:  22975874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycosphingolipids (GSLs) are components of the cell membrane that comprise a membrane bound lipid, ceramide, coupled to an extracellular carbohydrate. GSLs impact numerous aspects of membrane biology, including membrane fluidity, curvature, and organization. The role of these molecules in both chronic inflammation and infectious disease and underlying pathogenic mechanisms are just starting to be recognized. As a component of the cell membrane, GSLs are also incorporated into lipid bilayers of diverse enveloped viruses as they bud out from the host cell and can go on to have a significant influence on viral pathogenesis. Dendritic cell (DC) subsets located in the peripheral mucosal tissues are proposed to be one of the earliest cell types that encounter transmitted viruses and help initiate adaptive immune responses against the invading pathogen by interacting with T cells. In turn, viruses, as obligatory intracellular parasites, rely on host cells for completing their replication cycle, and not surprisingly, HIV has evolved to exploit DC biology for the initial transmission event as well as for its dissemination and propagation within the infected host. In this review, we describe the mechanisms by which GSLs impact DC-mediated HIV trans-infection by either modulating virus infectivity, serving as a direct virus particle-associated host-derived ligand for specific interactions with DCs, or modulating the T cell membrane in such a way as to impact viral entry and thereby productive infection of CD4(+) T cells.
Authors:
Wendy Blay Puryear; Suryaram Gummuluru
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  762     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-01-14     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-53     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Boston University School of Medicine, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Dendritic Cells / immunology*
Glycosphingolipids / physiology*
HIV Infections / immunology,  transmission*
HIV-1 / physiology*
Humans
Grant Support
ID/Acronym/Agency:
5T32AI007309-22/AI/NIAID NIH HHS; AI064099/AI/NIAID NIH HHS; AI081596/AI/NIAID NIH HHS; F32 AI084558/AI/NIAID NIH HHS; R01 AI064099/AI/NIAID NIH HHS; R21 AI081596/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Glycosphingolipids
Comments/Corrections

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